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KMID : 0364019990320040364
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Korean Journal of Thoracic and Cardiovascular Surgery
1999 Volume.32 No. 4 p.364 ~ p.367
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Clinical Study of the Effect of Aprotinin for Hemostasis in Open Heart Surgery
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Chung Sung-Woon
Kim Jong-Won
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Abstract
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Background: The efficacy of the hemostasis of prophylactic aprotinin after cardiac valve replacement was evaluated from January 1994 to December 1996 at Pusan National University Hospital.
Material and Method: In a randomized study, 20 patients received aprotinin(2×106 KIU as a loading dose for 30 minutes after anesthesia, 1×106 KIU for priming and 5×105 KIU/hr as a aintenance dose from the completion of loading dose till skin closure) and another 20 untreated patients served as controls.
Result: Aprotinin produced a significant reduction in postoperative blood loss compared with controls and significantly decreased total exposure to allogenic blood products compared with the control group(p<0.05).
Conclusion: We conclude that aprotinin effectively reduces postoperative blood loss and trasfusion in patient undergoing cardiac valve replacement.
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KEYWORD
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